甾体激素
類固醇激素 [ 1] [ 2] (英語:steroid hormone )又称甾体激素 [ 3] ,是一类四环脂肪烃 化合物 ,具有环戊烷 多氢菲 母核。类固醇激素是作为激素的类固醇。 这些包括性腺 的性激素 和肾上腺皮质 的皮质类固醇 。根据它们结合的类固醇受体,哺乳动物 类固醇激素可分为五组:糖皮质激素 、盐皮质激素 、雄激素 、雌激素 和孕激素 。
分类
類固醇激素
功能作用
发现及发展
參考
^ 生命科學名詞. 類固醇激素 . 樂詞網. 國家教育研究院. [2022-12-04 ] . (原始内容存档 于2022-12-04).
^ 生物化学与分子生物学名词. 类固醇激素 . 術語在線. 全国科学技术名词审定委员会. [2022-11-29 ] . (原始内容存档 于2022-11-29).
^ 药学名词第二版. 甾体激素 . 術語在線. 中国全国科学技术名词审定委员会. [2022-12-04 ] . (原始内容存档 于2022-12-04).
参见
延伸閱讀
Brook CG. Mechanism of puberty. Horm Res. 1999;51 Suppl 3:52–4. Review.PMID 10592444
Holmes SJ, Shalet SM. Role of growth hormone and sex steroids in achieving and maintaining normal bone mass. Horm Res. 1996;45(1–2):86–93. Review. PMID 8742125
Ottolenghi C, Uda M, Crisponi L, Omari S, Cao A, Forabosco A, Schlessinger D. Determination and stability of sex. Bioessays. 2007 Jan;29(1):15–25. Review. PMID 17187356
Couse JF, Korach KS. Exploring the role of sex steroids through studies of receptor deficient mice. J Mol Med. 1998 Jun;76(7):497–511. Review. PMID 9660168
McEwen BS. Steroid hormones: effect on brain development and function. Horm Res. 1992;37 Suppl 3:1–10. Review. PMID 1330863
Simons SS Jr. What goes on behind closed doors: physiological versus pharmacological steroid hormone actions. Bioessays. 2008 Aug;30(8):744–56. PMID 18623071
外部連結
受体
酶 (抑制剂 )
20,22-碳链裂解酶
22-ABC
3,3′-Dimethoxybenzidine
3-Methoxybenzidine
Aminoglutethimide
Cyanoketone
Danazol
Etomidate
Mitotane
Trilostane
17α-羟化酶, 17,20-裂合酶 3β-HSD (I, II) 17β-HSD (I-XIV) 5α還原酶 (I, II)
22-Oxime
Alfatradiol
Azelaic acid
β-Sitosterol
Bexlosteride
Dutasteride
表睾酮
Epristeride
Finasteride
Izonsteride
L-39
Lapisteride
Polyunsaturated fatty acids (α-linolenic acid, linoleic acid, γ-linolenic acid, oleic acid)
Turosteride
Vitamin B6
锌
芳香酶
1,4,6-Androstatriene-3,17-dione
4-Androstene-3,6,17-trione
4-Cyclohexylaniline
4-Hydroxytestosterone
5α-DHNET
Abyssinone II
Aminoglutethimide
Anastrozole
抗坏血酸(维生素C )
Atamestane
Bifonazole
CGP-45,688
CGS-47,645
Clotrimazole
双氢睾酮
Difeconazole
Econazole
Exemestane
Fadrozole
Fenarimol
Finrozole
Formestane
Imazalil
Isoconazole
Ketoconazole
Letrozole
Liarozole
MEN-11066
Miconazole
Minamestane
Nimorazole
NKS01
ORG-33,201
Penconazole
Plomestane
Prochloraz
Propioconazole
Pyridoglutethimide
Rogletimide
Rotenone
Talarozole
Testolactone
Tioconazole
Triadimefon
Triadimenol
Troglitazone
Vorozole
YM511
锌
Note: 21-Hydroxylase inhibitors may also affect androgen levels as they prevent metabolism of androgen steroid precursors.
其他
内源 间接
Estrogens/Antiestrogens (see here)
GnRH agonists/antagonists (see here )
Gonadotropins/Antigonadotropins (see here )
Plasma protein s (SHBG, ABP, Albumin)
Progestogens/Antiprogestins (see here )
Prolactin
操作
PR
受體致活劑 Mixed (SPRMs )
Apigenin
Asoprisnil
Asoprisnil ecamate
Guggulsterone
山柰酚
J1042
LG-120838
Naringenin
PRA-910
丁香酸
Telapristone
受體拮抗劑: 美服培酮
Org-31710
Org-33628
Ulipristal acetate
ZK-137316
Antagonists
3α-Hydroxytibolone
3β-Hydroxytibolone
阿来司酮
利洛司酮
洛那立生
奥那司酮
托立司酮
丙戊酸
维拉立生
扎诺特隆
ZM-150271
ZM-172406
mPRs (PAQRs )
受體致活劑
5α-Dihydroprogesterone
5β-Dihydroprogesterone
11-脱氧皮质酮
17α-Hydroxyprogesterone
17α,21-Dihydroxyprogesterone
Allopregnanolone
美服培酮
孕烯醇酮
孕酮
Antagonists
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