Bromfeniramin

Bromfeniramin
(IUPAC) ime
	3-(4-bromofenil)-N,N-dimetil-3-piridin-2-il-propan-1-amin
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a682545
Identifikatori
CAS broj	86-22-6
ATC kod	R06AB01
PubChem	6834
DrugBank	DB00835
ChemSpider	6573
UNII	H57G17P2FN
KEGG	D07543
ChEBI	CHEBI:3183
ChEMBL	CHEMBL811
Hemijski podaci
Formula	C16H19BrN2
Mol. masa	319,24 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 ; Key: ZDIGNSYAACHWNL-UHFFFAOYSA-N
Farmakokinetički podaci
Metabolizam	Hepatički
Poluvreme eliminacije	24,9 ± 9,3 sata
Izlučivanje	Urin
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije zaštićen, OTC
Način primene	Oralno

Bromfeniramin (Bromfed, Dimetap, Bromfeneks, Dimetan, BPN, Lodran) je antihistaminski leki iz klase propilaminskih alkilamina. On je dostupan na slobodno i koristi se za tretiranje simptoma prehlade i alergijskog rinitisa, kao što su curenje nosa, svrab očiju, vodnjikave oči, i kijanje. On spada u prvu generaciju antihistamina. Obično je u prodaji u obliku soli bromfeniramin maleata.

Bromfeniramin je deo serije antihistamina koja obuhvata feniramin (Naphcon) i njegove halogenovane derivate i druge, uključujući fluorfeniramin, hlorfeniramin, dekshlorfeniramin (Polaramin), deshlorfeniramin, difeniramin (takođe poznat kao triprolidin sa trgovačkim imenom Aktifed), i jodofeniramin.

Bromfeniramin ima antidepresantna svojstva, inhibiciju ponovnog preuzimanja neurotransmitera serotonina.^[7]

Reference

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Simons FE, Frith EM, Simons KJ (December 1982). „The pharmacokinetics and antihistaminic effects of brompheniramine”. The Journal of Allergy and Clinical Immunology 70 (6): 458–64. PMID 6128358.
↑ Barondes, Samuel H. (2003). Better Than Prozac. New York: Oxford University Press. str. 39–40. ISBN 0-19-515130-5.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid6128358-6] Simons FE, Frith EM, Simons KJ (December 1982). „The pharmacokinetics and antihistaminic effects of brompheniramine”. The Journal of Allergy and Clinical Immunology 70 (6): 458–64. PMID 6128358.

[Barondes-7] Barondes, Samuel H. (2003). Better Than Prozac. New York: Oxford University Press. str. 39–40. ISBN 0-19-515130-5.

[1]

[2]

[3]

[4]

[5]

[6]

[7]